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Coagulation Corner

Tuesday, October 3, 2017

October 2017 - World Thrombosis Day

Written By Donna Castellone, MS, MT (ASCP) SH | LinkedIn

Sign up for the WTD 2017 Thunderclap and pledge your support!



Tuesday, September 5, 2017

Diagnosing Factor Deficiences

Written By Donna Castellone, MS, MT (ASCP) SH | LinkedIn

How is your coagulation laboratory at diagnosing patients with factor deficiencies? What impacts your laboratories capacity for detecting levels that correlate with the patients’ clinical diagnosis?



Monday, August 1, 2017

Overview of the ISTH Conference

Written By Donna Castellone, MS, MT (ASCP) SH | LinkedIn

The field of coagulation has expanded not only in scope, knowledge but also in practice. No longer is it a "need to know" basis. With all of the new drugs, the prevalence of thrombosis and still a population of patients with unexplained bleeding or stroke- everyone wants to understand and learn what is going on in this discipline.




Wednesday, July 5, 2017

Guidelines: Do We Need Them? Should We Use Them? Are They Helpful?

Written By Donna Castellone, MS, MT (ASCP) SH | LinkedIn

Coagulation laboratories are always looking for help. Coagulation testing has lots of challenges- different reagents with different sensitivities, different types of deficient plasma, different methodologies, standard curves, calibrators- you can mix and match or stick to what is matched to your analyzer. Add in different technologists running assays and adding their own touch and interpretation, it amazing any results get reported with confidence!



Wednesday, May 31, 2017

June 2017 ISLH: Hawaii - Hot Topics

Written By Donna Castellone, MS, MT (ASCP) SH | LinkedIn

The ISLH meeting took place his May in beautiful Hawaii. Not only was the weather hot, but the topcis were also. Here are a few of the highlights!



Tuesday, May 02 2017

Factor XIII

Written By Donna Castellone, MS, MT (ASCP) SH | LinkedIn

There are a few parameters that are not measured in the routine screening tests of the PT and aPTT. One are platelets and the other is a FXIII deficiency. Fibrin Stabilizing Factor was discovered in 1944 by Robbins. It occurs in 1 in 2 million births and inheritance pattern is autosomal recessive.



Wednesday, April 04, 2017

Biological Variation in Coagulation

Written By Donna Castellone, MS, MT (ASCP) SH | LinkedIn

HAPPY NATIONAL MEDICAL LABORATORY WEEK! All stars laboratory week: teaming up for patient care!




Monday, March 6, 2017

What Policies Do We Need In The Coagulation Laboratory?

Written By Donna Castellone, MS, MT (ASCP) SH | LinkedIn

Rules, regulations, policies can in many cases can complicate what we do in the laboratory. But there are many policies that need to be part of ensuring quality in the coagulation laboratory.



Saturday, February 4, 2017

Coagulation and Laboratory Developed Tests

Written By Donna Castellone, MS, MT (ASCP) SH | LinkedIn

Laboratory Developed Test (LDTs) are tests that laboratories develop according to their own procedures. Many of these are known as "in house tests: and have no manufacturer kit. Why are these so important?



Tuesday, January 3, 2017

Commonly Asked Coagulation Questions!

Written By Donna Castellone, MS, MT (ASCP) SH | LinkedIn

I am asked many questions in coagulation, so I thought to start off the new year, I would share some of the most commonly asked questions and my thoughts.



Monday, December 5, 2016

THE HOLIDAYS... AND WHAT ELSE - COAGULATION!

Written By Donna Castellone, MS, MT (ASCP) SH | LinkedIn

Welcome to the Holiday edition of Coagulation Corner! No matter what your beliefs or what group you belong to or do not belong to, everyone celebrates something. They may not be the same day for everyone, but working in a diverse environment and talking with people, there are similarities. They involve family, food, travel and many times stress! How does coagulation work its way into these events, stay with me, and I will show you.



Tuesday, November 8, 2016

The Coagulation Cascade

Written By Donna Castellone, MS, MT (ASCP) SH | LinkedIn

Ah, the mysteries of life- the Bermuda triangle, the lost city of Atlantis, the WOW theory, and Mayan civilization. Some might even add the coagulation cascade to that list. It instills fear and confusion in students, residents and technologists alike. It is complicated with all factors, and inhibitors displaying the intrinsic, extrinsic, common and fibrinolytic systems. Or is can be as simple as- tissue factor becomes activated, then a miracle occurs and a clot forms! It was Paul Morawitz in 1905 that assembled coagulation factors into the scheme of coagulation which demonstrated that in the presence of calcium and thromboplastin, prothrombin (II) was converted to thrombin which in turn converted fibrinogen (I) into a fibrin clot. This theory persisted for 40 years until Paul Owren, in 1944, discovered a bleeding patient that a four factor concept of clotting could not apply, thus factor V was discovered.





 




NEW BLOGS


October 2017 - World Thrombosis Day


Diagnosing Factor Deficiences


Overview of the ISTH Conference


Guidelines: Do We Need Them? Should We Use Them? Are they Helpful?


June 2017 ISLH: Hawaii - Hot Topics


Factor XIII


Biological Variation in Coagulation





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